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"Smokers have been telling us that our new plain packaging and larger graphic health warnings are putting them off," said Australian health minister Tanya Pilbersek

This is an important consideration, given that smokers with COPD are known to perform poorly in smoking cessation programs due to their high relapse rate

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You have to keep in mind that the cost of tobacco is different in every state and country based on regulations and tobacco taxes

Epigenetic changes are alterations that don't change the sequence of DNA, but rather affect whether certain genes are turned "on" or "off." One specific type of epigenetic change the researchers looked for is called "methylation," in which a small molecule is added to a part of the DNA, preventing that section from being turned on